Reporting associations between dietary supplements and adverse events.

Reporting associations between dietary supplements and adverse events.: Mayo Clin Proc. Author: Michael McGuffin
To the Editor: The article by Gange et al, published in the April 2006 issue of Mayo Clinic Proceedings, purported to document an association between bitter orange peel extract and variant angina in a borderline-obese 57-year-old man. However, the authors’ identification of bitter orange as the offending ingredient must be considered speculative. It would be no more accurate to assume that any of the other 9 ingredients in the supplement, or the drugs, or other supplements the patient was taking concomitantly, were the cause of the patient’s angina.

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