Inhibitory effect of thai plant extracts on P-glycoprotein mediated efflux.

Inhibitory effect of thai plant extracts on P-glycoprotein mediated efflux.: Phytother Res. 2006 Jan 5;20(1):79-81 Authors: Junyaprasert VB, Soonthornchareonnon N, Thongpraditchote S, Murakami T, Takano M

Curcuminoids from Curcuma longa L. and extracts of Psidium guajava L., Andrographis paniculata (Burm. f.) Nees, Phyllanthus emblica L. and Solanum trilobatum L. were investigated for their inhibitory effect on P-glycoprotein (P-gp) on the efflux transport of rhodamine 123 (Rho-123 ) in Caco-2 cells and rat ileum. Of the five tested samples, curcuminoids and an extract of P. guajava showed the highest inhibitory effect on P-gp mediated efflux of Rho-123 in Caco-2 cells. Additionally, they were found to have equal potential in inhibiting Rho-123 efflux transport from serosal to mucosal surfaces of the rat ileum. Copyright (c) 2006 John Wiley & Sons, Ltd.

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